| Pair Name | Homoharringtonine, Daunorubicin | ||
| Phytochemical Name | Homoharringtonine (PubChem CID: 285033 ) | ||
| Anticancer drug Name | Daunorubicin (PubChem CID: 30323 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Daunorubicin |
| Adverse Reactions | Myelosuppression, ulcerative stomatitis, fever, rash. This was inferred hot nature anticancer drug. |
| Recommendations | Cold: Cephalotaxus fortunei; Cephalotaxus sinensis; Cephalotaxus fortunei |
| Reference | ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899. ref_link |
| Pair Name | Homoharringtonine, Daunorubicin | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in S phase | |||
| In Vitro Model | HL‐60 | Adult acute myeloid leukemia | Homo sapiens (Human) | CVCL_0002 |
| K-562 | Blast phase chronic myelogenous leukemia | Homo sapiens (Human) | CVCL_0004 | |
| In Vivo Model | 6–8 weeks old female BALB/c nude mice were injected with 1.0 × 107 HL60 cells subcutaneously in the right flank. When the solid tumor volume reached about 100 mm3, the mice were randomly assigned into 4 groups (7 mice per group): saline group, free DNR+HHT group, DH-LP group, FA-DH-LP group. | |||
| Result | FA-DH-LP might present a promising delivery strategy to improve the efficacy of the two combinational chemotherapeutics while reducing toxicity | |||
| No. | Title | Href |
|---|---|---|
| 1 | Co-Delivery of Daunorubicin and Homoharringtonine in Folic Acid Modified-Liposomes for Enhancing Therapeutic Effect on Acute Myeloid Leukemia. J Pharm Sci. 2023 Jan;112(1):123-131. doi: 10.1016/j.xphs.2022.04.014. | Click |
